Tec-Control Chromatography

For radiopharmaceutical quality control

Tec-Control Chromatography

Tec-Control Chromatography tests the radiochemical purity of specific Tc-99m-labeled radiopharmaceuticals. The accompanying chart shows which strips and solvents are required to perform each individual test. Some solvents must be purchased separately (see Sigma-Aldrich chart) due to hazardous material shipping restrictions.

Detailed instruction manuals are packaged with each strip container, although our Radiopharmaceutical QC Procedure Manual (151-000) explains paper chromatography in greater detail.

Tec-Control Aluminium Breakthru Kit

Tec-Control Aluminium Breakthru Kit

Simple 3-step procedure

The Aluminum Breakthru Kit provides a rapid, easy and inexpensive way to test aqueous solutions, particularly pertechnetate generator eluate, for trace quantities of aluminum. Aluminum forms an intense red precipitate with the indicator paper, and the intensity of the color is directly proportional to the amount of aluminum in the solution. The USP allows a concentration of aluminum ion in an injection µ10 micrograms per milliliter (10 µg/ml) in technetium 99m eluate prepared from Molybdenum 99 formed as a result of uranium fission.

Simple Procedure:

  1. Place a drop of the eluate or solution to be tested on the indicator paper. The best procedure is to form a hanging drop using a 19-22G needle.
  2. Place a drop of the standard aluminum solution on the indicator paper. Use the same size drop.
  3. Compare the intensity of the red spot formed. If the eluate spot is less intense than the standard solution, the eluate contains less than 10µg/ml aluminum.
150-780 Chromatography Kit, Tec-Control
Aluminum Breakthru Kit includes:
Aluminum standard, 5 ml, 10 ug/ml,
50 indicator strips and manual

Radiopharmaceutical QC Manual

Radiopharmaceutical QC Manual

This 90-page manual explains Paper Chromatography, a QC method for evaluating the radiochemical purity of currently used Tc-99m-labeled radiopharmaceuticals. Procedures are quick and easy to use, a simple quality control solution for any nuclear medicine department.

151-000 Procedure Manual,
Radiopharmaceutical QC

References:

Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals; A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230. Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis, A. Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center, Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1.


RADIOPHARMACEUTICAL SOLVENT(S) REQUIRED* STRIPS REQUIRED
Aluminum Breakthru 150-781 150-782
Bicisate (Neurolite™) Ethyl Acetate 99.% 150-130
Diphosphonate Acetone (HPLC Grade), Distilled H2O 150-001 & 150-005
Disofenin (Hepatolite™) 150-160, Distilled H2O 150-122 & 150-125
DMSA Acetone (HPLC Grade), 150-025
DTPA Acetone (HPLC Grade), Distilled H2O 150-001 & 150-005
Exametazine (Ceretec™) Ethyl Acetate 99.% 150-130
Glucoheptonate Acetone (HPLC Grade), Distilled H2O 150-001 & 150-005
HDP Acetone (HPLC Grade), Distilled H2O 150-001 & 150-005
MAA Acetone (HPLC Grade), 150-001
MAG3 (Mertiatide™) Acetone, (HPLC Grade),
Chloroform 99.8%
Tetrahydrofuran 99+% 		150-951 & 150-952
MDP Acetone (HPLC Grade), Distilled H2O 150-001 & 150-005
Mebrofenin (Cholotec™) 150-160, Distilled H2O 150-122 & 150-125
Pyrophosphate Acetone (HPLC Grade), Distilled H2O 150-001 & 150-005
Sestamibi (Cardiolite™ and Miraluma™ Ethyl Acetate 99.% 150-991
Sulphur Colloid Acetone (HPLC Grade) 150-001
Tc-99m (reduced) Acetone (HPLC Grade), 150-001
Tc-99m Monocolonal Antibodies 0.9% Saline 150-771
Tetrofosmin (Myoview™) Ethyl Acetate 99.% 150-971
In-111, Octreotide (Octreoscan™) 150-773 & 0.9% Saline 150-771 **
In-11 Monocolonal Antibodies 150-773 & 0.9% Saline 150-771 **
In-111/Y-90 Zevalin™ 150-773 & 0.9% Saline 150-771
I-131 Monoclonal Antibodies
And Neutrospec™ 		0.9% Saline 150-771
* See Sigma-Aldrich product matrix for solvents.
** Note: A Well Plate is suggested to perform QC on these radiopharmacuticals

Chromatography Strips
150-001 Strips, RED, 50/pkg
150-005 Strips, BLACK, 50/pkg
150-025 Strips, YELLOW, 50/pkg
150-122 Strips, ORANGE, 50/pkg
150-125 Strips, LIGHT BLUE, 50/pkg
150-130 Strips, GOLD, 50/pkg
150-771 Strips, DARK GREEN, 50/pkg
150-951 Strips, LIME, 50/pkg
150-952 Strips, PEACH, 50/pkg
150-971 Strips, TEAL, 50/pkg
150-991 Strips, PINK, 50/pkg
150-782 Strips, ALUMINUM, 50/pkg

Chromatography Solvents
150-160 Solvent, 20% Sodium Chloride, 30 ml
150-773 Solvent, DTPA, 5 ml
150-781 Solvent, Aluminum Standard, 5 ml, 10 µg/ml

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